The Wyeth / Wythe family is American history in action. The family has been on the forefront of the American story since Nicholas Wyeth came to the Massachusetts Bay Colony around the time of the Great Migration.

They struggled through King Philip's War, suffered cruelly in the Salem Witch Trials, protested taxation without representation in the Boston Tea Party, marched as minutemen on the first day of the American Revolution, served in General George Washington's Continental Army, and battled for both the North and the South in the Civil War. Striving to thrive in times of war and peace, Wyeth / Wythe families helped build America. Their occupations ranged from masons to farmers, from teachers to undertakers, from architects to drug company founders and from well-known explorers to iconic artists.

Family stories are wide ranging as well. George McClelland Wyeth stealing chickens in Monongahela, Pennsylvania to feed his ten motherless children in 1906 is light years away from the 1910 high society party of George Edward Wyeth's debutante daughter, Charlotte Grosvenor Wyeth, on 42nd Street in New York City, New York. Nevertheless, their stories are equally American. The family stories in this book were born of the aspirations of one man, Nicholas Wyeth, when he bravely set his sights on a strange new world over 3,000 miles away from the familiar golden fields of his home in Suffolk County, England.

This book is enhanced with numerous photographs, documents, endnotes, a bibliography and a name index. It is divided into two sections. The first section includes theories for the connection of Declaration of Independence signer George Wythe to Nicholas Wyeth, a history of the bigamy charge brought against one of Cambridge's most affluent Wyeths, and details for some of Nicholas Wyeth's famous descendants.

The second section uses the register numbering format to name and give statistics for the descendants of Nicholas Wyeth from his children to his fifth great grandchildren.