A girl who'd rather carry out dissections on a snowy back porch than join her family for Christmas dinner is a strange and exotic artifact in the town of Sleeping Bay.

But by her early twenties, Lottie finds herself trapped in a marriage gone stale, with a daughter she adores but whose existence jeopardizes her place in the lab and her dream of becoming a scientist. How can a young woman make her way in a world determined to contain her brilliance, her will, and her longing to live?

Bravely and wisely written, Artifact is an intimate and propulsive portrait of a whole woman, a celebration of her refusal to be defined by others’ imaginations, and a meditation on the glorious chaos of biological life.